Prostaglandin E2 (PGE2) signaling is a research area focused on understanding the role and mechanisms of action of the lipid mediator prostaglandin E2 in various physiological and pathological processes. PGE2 is produced by the enzymatic conversion of arachidonic acid and plays a key role in inflammation, pain signaling, fever response, and regulation of various cell functions. Researchers study the signaling pathways activated by PGE2, including its interactions with specific receptors (EP1, EP2, EP3, EP4) on target cells, and the downstream effects on intracellular signaling cascades. Dysregulation of PGE2 signaling has been implicated in a variety of diseases, including cancer, cardiovascular disorders, and inflammatory conditions. Understanding PGE2 signaling is important for developing therapeutic strategies targeting this pathway for the treatment of various diseases. Researchers investigate the potential of modulating PGE2 signaling with pharmacological agents, gene therapy, or dietary interventions to manage and prevent disease progression.